Wellbutrin Bupropion Hcl: Side Effects, Uses, Dosage, Interactions, Warnings

In the third trial, outpatients were treated with 300 mg per day of WELLBUTRIN. This trial demonstrated the efficacy of WELLBUTRIN as measured by the HDRS total score, the HDRS Item 1, the Montgomery‑Asberg Depression Rating Scale (MADRS), the CGI-S score, and the CGI-Improvement Scale (CGI-I) score. Effectiveness of WELLBUTRIN in long‑term use, that is, for more than 6 weeks, has not been systematically evaluated in controlled trials.

Clinical Pharmacology for Wellbutrin

Bupropion is an antidepressant used for smoking cessation and to treat a variety of conditions, including depression and other mental/mood disorders. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience new or worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. In the first trial, the dose range of WELLBUTRIN was 300 mg to 600 mg/day administered in 3 divided doses; 78% of subjects were treated with doses of 300 mg to 450 mg/day. The second trial included 2 doses of WELLBUTRIN (300 and 450 mg/day) and placebo. This trial demonstrated the effectiveness of WELLBUTRIN for only the 450-mg/day dose.

International Patients

If you have a seizure while taking WELLBUTRIN, stop taking the tablets and call your healthcare provider right away. A single-dose pharmacokinetic trial demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that of younger subjects. The effect of hepatic impairment on the pharmacokinetics of bupropion was characterized in 2 single-dose trials, one in subjects with alcoholic liver disease and one in subjects with mild-to-severe cirrhosis. The first trial demonstrated that the half-life of hydroxybupropion was significantly longer in 8 subjects with alcoholic liver disease than in 8 healthy volunteers (32 ± 14 hours versus 21 ± 5 hours, respectively). Although not statistically significant, the AUCs for bupropion and hydroxybupropion were more variable and tended to be greater (by 53% to 57%) in volunteers with alcoholic liver disease.

NEUROPHARMACOLOGY AND MECHANISM OF ACTION OF BUPROPION

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.

Smoking Quiz: How to Quit Smoking

You will want to find a medication that is both tolerable and effective. Your provider will be able to work with you to get to the root of the problem and help you find a solution. Do not take more Wellbutrin than your doctor prescribes, as this can lead to serious side effects. If you take too much Wellbutrin, your doctor may monitor you closely for signs and symptoms of overdose.

Mental Health

The drug has a boxed warning for this side effect, which is the most severe drug warning issued by the Food and Drug Administration (FDA). But studies of people taking Wellbutrin XL for seasonal affective disorder (SAD) have reported flatulence, which wasn’t reported in studies of Wellbutrin SR. No, Wellbutrin XL and Wellbutrin SR shouldn’t cause different side effects. This is because both forms of the drug have the same active ingredient, which is bupropion. If you are using bupropion to quit smoking and experience any of these symptoms, stop taking it and contact your doctor right away. Also, tell your doctor right away if you have any of these symptoms after stopping treatment with bupropion.

You should refer to the prescribing information for Wellbutrin for a complete list of interactions. You may notice an odor from the tablets; this is normal and does not affect how they work. Lab and/or medical tests (such as blood pressure, liver function) may be done while you are taking this medication. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Do not use an MAO inhibitor within 14 days before or 14 days after you take Wellbutrin XL. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

The efficacy of WELLBUTRIN in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies]. Advise families and caregivers of the need for close observation and communication many at risk for alcohol-medication interactions national institutes of health nih with the prescriber [see WARNINGS AND PRECAUTIONS]. There are no adequate studies of Wellbutrin in pregnant women. In one study, there was no difference between Wellbutrin and other antidepressants in the occurrence of birth defects. Wellbutrin passes into breast milk and may harm a nursing baby.

1. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared.
2. Considered in aggregate, these data demonstrate that bupropion inhibits the reuptake of norepinephrine and dopamine in humans without affecting release or transport of other neurotransmitters and without binding to other neurotransmitter receptors.
3. Doctors will prescribe Wellbutrin SR in adults to treat major depressive disorder (MDD).
4. When rats were administered bupropion at oral doses of up to 300 mg per kg per day (approximately 7 times the MRHD on a mg per m2 basis) prior to mating and throughout pregnancy and lactation, there were no apparent adverse effects on offspring development.
5. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal.

Wellbutrin is the brand name for bupropion, which is neither an SSRI nor an SNRI, but rather an NDRI. Bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, Aplenzin) is used to treat depression. Bupropion (Wellbutrin XL, Aplenzin) can also be used to treat seasonal affective disorder (SAD), which is a subtype of depression, and bupropion addiction as a coping mechanism and healthy alternatives (Zyban) is used as part of a treatment plan to help people stop smoking. Wellbutrin works by preventing your body from reabsorbing norepinephrine and dopamine, which can lessen symptoms of anxiety and depression. Wellbutrin (bupropion) is prescribed to treat major depressive disorder (MDD) and prevent seasonal affective disorder (SAD).

Because it may take several weeks to see the full effects of this medication, it is important to continue your treatment as prescribed. It helps regulate your mood by increasing norepinephrine and dopamine hormones in your brain. Bupropion oral tablet is used for long-term treatment of depression or SAD.

Do not start taking bupropion during the 2 weeks after you stop a MAO inhibitor. Wait for 2 weeks after stopping bupropion before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking bupropion who continued to smoke. the dangers of drinking after work Although WELLBUTRIN® is not approved for smoking cessation, observe all patients for neuropsychiatric reactions. Instruct the patient to contact a healthcare provider if such reactions occur [see Warnings and Precautions (5.2)].

Your doctor can help you figure out whether your medication, your condition, or both are causing suicidal thoughts and behaviors. If you have suicidal thoughts or behaviors with Wellbutrin, your doctor will have you stop taking it. But your risk of suicidal thoughts and behaviors may continue after you stop taking the drug. The most severe long-term side effect is suicidal thoughts and behaviors.

This medicine can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication. Tell your healthcare provider about all the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. Many medicines increase your chances of having seizures or other serious side effects if you take them while you are taking WELLBUTRIN.